H. R. GRALNICK, M.D.; J. S. FINLAYSON, PH.D.
Despite its molecular heterogeneity (1, 2), a relatively constant set of functional properties has been ascribed to human fibrinogen (3). It is, therefore, of considerable clinical, genetic, and biochemical importance that within the last decade several hereditary functional defects of fibrinogen have been described. These disorders of familial, qualitatively abnormal fibrinogens have been most commonly referred to as congenital dysfibrinogenemias (4).
Congenital variants of fibrinogen are usually first noticed during coagulation tests in which plasma fibrinogen is converted to fibrin—that is, thrombin time, Reptilase time, or prothrombin time. The times are generally prolonged; in some cases no clot forms at
Learn more about subscription options.
Register Now for a free account.
GRALNICK HR, FINLAYSON JS. Congenital Dysfibrinogenemias. Ann Intern Med. 1972;77:471–473. doi: 10.7326/0003-4819-77-3-471
Download citation file:
Published: Ann Intern Med. 1972;77(3):471-473.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only