TERRENCE F. BLASCHKE, M.D.; RONALD J. ELIN, M.D., Ph.D.; PAUL D. BERK, M.D., F.A.C.P.; CHULL S. SONG, M.D., Ph.D., F.A.C.P.; SHELDON M. WOLFF, M.D., F.A.C.P.
BLASCHKE TF, ELIN RJ, BERK PD, SONG CS, WOLFF SM. Effect of Induced Fever on Sulfobromophthalein Kinetics in Man. Ann Intern Med. 1973;78:221-226. doi: 10.7326/0003-4819-78-2-221
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Published: Ann Intern Med. 1973;78(2):221-226.
The effect of fever induced by endotoxin or etiocholanolone on sulfobromophthalein (BSP) kinetics was examined in 20 healthy volunteers by analyzing the plasma disappearance curves obtained after a single injection of 5.0 mg/kg body weight of BSP during the fever. In addition to 45-minute retention, BSP clearances, the values for the parameters of a compartmental model of BSP metabolism, and relative hepatic BSP storage capacity were calculated by computer from the experimental curves. Although only 9 of the 20 fever volunteers had abnormal BSP retention at 45 minutes, all pyrogen-treated subjects had significant changes in values for the compartmental parameters. The largest changes were in the values for BSP reflux from liver to plasma, which increased to 587% of control values, and for relative hepatic BSP storage capacity, which fell by 46%. These results indicate that caution must be used in interpreting the BSP test in patients who are even mildly febrile.
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Esophageal Disorders, Gastroenterology/Hepatology, Gastroesophageal Reflux Disease, Liver Disease, Peptic Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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