Bernard M. Patten, M.D.; John Belizikian, M.D.; Lawrence Mallette, M.D.; Alan Prince, M.D.; Gerald Aurbach, M.D.; W. King Engel, M.D.
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We report the first detailed study of the neurological, electromyographic, and muscle biopsy findings in patients with hyperparathyroidism.
Over 80% of our 16 patients presented with a distinct syndrome consisting of easy fatigability; weakness and atrophy of proximal muscles, particularly of the leg; tongue tremors; and normal or hyperactive reflexes. The presence or severity of weakness bore no relationship to the alteration of any serum ion measured, including calcium. The electromyograms showed short-duration, low-amplitude complex and, sometimes, polyphasic potentials mingled with high-amplitude, long-duration motor units. Motor and sensory nerve conduction times were normal. Muscle biopsies showed neurogenic atrophy of both
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Patten BM, Belizikian J, Mallette L, Prince A, Aurbach G, Engel WK. Hyperparathyroid Neuromuscular Disease.. Ann Intern Med. 1973;78:815–816. doi: 10.7326/0003-4819-78-5-815_4
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Published: Ann Intern Med. 1973;78(5):815-816.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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