Daniel Hollander, M.D.; John Harlan, M.D.
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The ability of antacids to relieve discomfort and to promote healing of peptic ulcerations was compared with that of placebos in a randomized double-blind study. Seventy-three patients with radiologically or endoscopically proved active peptic ulcerations were randomly assigned to placebo-treated or antacid-treated groups and were followed and evaluated in a double-blind fashion. They were studied as outpatients and ate a regular diet, avoiding only caffeine, alcohol, and salicylates. Pain relief was assessed after 3 days and healing after 30 days of therapy.
In patients with duodenal ulcerations, 25 of 29 treated with antacids had pain relief, as compared with 17
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Hollander D, Harlan J. Controlled Double-Blind Evaluation of Antacids and Placebos in Peptic Ulcer Therapy.. Ann Intern Med. 1973;78:818. doi: 10.7326/0003-4819-78-5-818_1
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Published: Ann Intern Med. 1973;78(5):818.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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