Anthony Melaragno, B.S.; Patrick W. Flanigan, M.D.; Philip A. Bromberg, M.D., F.A.C.P.; Stanley P. Balcerzak, M.D., F.A.C.P.
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Cyanate therapy of sickle-cell disease is currently under investigation. Since cyanate-treated erythrocytes have increased oxygen affinity, we studied the effect of chronic cyanate administration on tissue oxygen delivery in rats. Sodium cyanate (CNO) was administered for 8 weeks to two groups of rats. Thirty received 625 mg/kg body weight-week orally, and 30 received 250 mg/kg body weight-week intraperitoneally. Control animals received equivalent amounts of NaCl. Animals were killed at 2, 4, and 8 weeks, and blood oxygen affinity (P50), erythrocyte 2, 3-diphosphoglycerate (DPG), hematocrit, and erythrocyte mass were measured. Tissue oxygen delivery was assessed by skin bubble oxygen tension (SBpO2).
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Melaragno A, Flanigan PW, Bromberg PA, Balcerzak SP. Impaired O2 Delivery in Cyanate-Treated Animals.. Ann Intern Med. 1973;78:823. doi: 10.7326/0003-4819-78-5-823_2
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Published: Ann Intern Med. 1973;78(5):823.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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