Kenneth A. McKusick, M.D.; Peter T. Kirchner, M.D.; Leon Malmud, M.D.; Melville Williams, M.D.; Henry N. Wagner Jr., M.D., F.A.C.P.; T. K. Natarajan
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A fall in renal blood flow has been shown to be one of the earliest pathophysiologic signs of renal graft rejection. Computer-assisted regional quantitation of serial gamma camera images of the kidney, after intravenous injection of 10 mCi 99mTc-diethylenetriaminepentacetic acid, provides both an accurate measure of renal blood transit time and a quantitative index of total renal blood flow.
Radioactivity over abdominal aorta and the transplant was continuously recorded with a gamma camera onto magnetic tape, in consecutive 3-sec intervals for the first minute. After light pen selection of regions of interest from the serial images, time activity curves were
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McKusick KA, Kirchner PT, Malmud L, Williams M, Wagner HN, Natarajan TK. The Radioisotopic Differentiation of Acute Tubular Necrosis from Rejection in Clinical Renal Transplantation.. Ann Intern Med. 1973;78:827. doi: 10.7326/0003-4819-78-5-827_2
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Published: Ann Intern Med. 1973;78(5):827.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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