R. A. Grossman, M.D.; R. W. Hamilton, M.D.; B. M. Morse, M.D.; A. S. Penn, M.D.; Martin Goldberg, M.D., F.A.C.P.
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In the past 3 years we have observed 15 cases in which myoglobinuria, in the absence of surgery or trauma, was the sole identifiable cause of ensuing acute tubular necrosis. Myoglobin, positively identified by acrylamide gel electrophoresis and immunodiffusion, was found in the urine of all patients and in the serum of eight patients. Gross pigmenturia was often not present; but pigmented granular casts were always seen in the urine sediment. A positive ortho-toluidine test (Hematest) of the urine, in the absence of red cells, microscopically, was a frequent finding. Unique features included a strikingly elevated serum Phosphokinase value; rapidly
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Grossman RA, Hamilton RW, Morse BM, Penn AS, Goldberg M. Nontraumatic Myoglobinuria as a Cause of Acute Tubular Necrosis.. Ann Intern Med. 1973;78:827. doi: 10.7326/0003-4819-78-5-827_3
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Published: Ann Intern Med. 1973;78(5):827.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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