RICHARD S. STEIN, M.D.; ROBERT W. COLMAN, M.D., F.A.C.P
A 16-year-old hemophiliac with a circulating inhibitor to factor VIII was treated with cyclophosphamide, prednisone, and large doses of factor VIII concentrates. Therapeutic levels of factor VIII were obtained, the patient responded clinically, and the inhibitor disappeared completely by the 19th day. When bleeding episodes recurred on two separate occasions, infusions of factor VIII failed to provide a reappearance of the antibody despite the absence of further immunosuppressive treatment. Providing that the titer is such that antigen excess can be obtained, this therapeutic approach may be useful not only in eliminating factor VIII inhibitors but also in preventing the usually observed anamnestic response.
Learn more about subscription options.
Register Now for a free account.
STEIN RS, COLMAN RW. Hemophilia with Factor VIII Inhibitor: Elimination of Anamnestic Response. Ann Intern Med. 1973;79:84–87. doi: 10.7326/0003-4819-79-1-84
Download citation file:
Published: Ann Intern Med. 1973;79(1):84-87.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only