JOHN Q. STAUFFER, M.D.; MICHAEL H. HUMPHREYS, M.D.; G. JOHN WEIR, M.D., F.A.C.P.
STAUFFER JQ, HUMPHREYS MH, WEIR GJ. Acquired Hyperoxaluria with Regional Enteritis After Ileal Resection: Role of Dietary Oxalate. Ann Intern Med. 1973;79:383-391. doi: 10.7326/0003-4819-79-3-383
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Published: Ann Intern Med. 1973;79(3):383-391.
Urinary oxalate excretion was measured in 11 patients with inflammatory bowel disease involving the terminal ileum. Group A consisted of six patients with minimal or no resection of terminal ileum and group B of six patients with resections greater than 30 cm. Basal urinary oxalate excretion was normal in group A but was significantly elevated in group B. After treatment with oral cholestyramine, a drug known to bind bile salts, urinary oxalate excretion fell promptly in group B to within the normal range but remained unchanged in group A. Five of six patients in group B had severe, explosive, watery diarrhea, which was dramatically reversed by cholestyramine. Hyperoxaluria in two patients was reversed when oxalate was removed from the diet, and in-vitro studies showed that cholestyramine binds oxalic acid. These data suggest that the mechanism of acquired hyperoxaluria in patients with ileal resection is related to enhanced absorption of dietary oxalate.
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Gastroenterology/Hepatology, Inflammatory Bowel Disease, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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