HOWARD RUBINOFF, M.D.
To the editor: I would appreciate it if Dr. Frohlich could document his suggestion (Ann Intern Med 78: 717-723, 1973) that the "loop of Henle" diuretics may be more effective than the thiazides in the management of hypertension in patients with renal functional impairment. I am not aware of any studies substantiating this statement; to the contrary, Dr. Anderson and his colleagues (Q J Med 40:541-560, 1971) concluded that the thiazides were twice as effective as "frusemide" (furosemide) in the treatment of hypertension. The loop diuretics are more expensive and potentially more harmful than the thiazides.
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RUBINOFF H. Diuretics in Hypertension. Ann Intern Med. 1973;79:455. doi: 10.7326/0003-4819-79-3-455_1
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Published: Ann Intern Med. 1973;79(3):455.
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