JOSEPH A. LIBNOCH, M.D.
To the editor: The demonstration by McPhedran and colleagues (1) that half of all patients with significant macrocytosis have a deficiency of vitamin B12 or folate, or both, indicates the importance of scrutinizing the erythrocyte indexes recorded by the Coulter Counter, even when there are reasonably satisfactory hemoglobin levels. But the assignment by the authors of another quarter of their 100 patients to the categories of macrocytosis with liver disease and alcoholism tends to perpetuate the concept that macrocytosis with liver disease is a distinct etiologic entity. The thin macrocyte of liver disease seems to be a legitimate entity,
Learn more about subscription options.
Register Now for a free account.
LIBNOCH JA. Macrocytosis. Ann Intern Med. 1973;79:456–458. doi: 10.7326/0003-4819-79-3-456
Download citation file:
Published: Ann Intern Med. 1973;79(3):456-458.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only