GERMÁN RAMÍREZ, M.D.; WILLIAM JUBIZ, M.D.; CHARLEY F. GUTCH, M.D., F.A.C.P.; H. ALLAN BLOOMER, M.D., F.A.C.P.; RICHARD SIEGLER, M.D.; WILLEM J. KOLFF, M.D.
Fifty-three patients with renal failure on chronic hemodialysis were screened for the presence of goiter. Thirty-one had enlarged thyroid glands, a prevalence of goiter of 58% not previously reported. Thyroid function studies showed low 131I uptakes, low serum thyroxine and normal serum triiodothyronine and thyrotrophic hormone levels. Serum concentrations of thyroxine-binding globulin were normal; serum albumin concentration was only slightly reduced. Administration of synthetic thyrotrophin-releasing hormone was followed by a rise in serum thyrotrophin and triiodothyronine levels. The cause of the goiter is not known. The possibility that goitrogenic substances are involved is discussed.
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RAMÍREZ G, JUBIZ W, GUTCH CF, BLOOMER HA, SIEGLER R, KOLFF WJ. Thyroid Abnormalities in Renal Failure: A Study of 53 Patients on Chronic Hemodialysis. Ann Intern Med. 1973;79:500–504. doi: 10.7326/0003-4819-79-4-500
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Published: Ann Intern Med. 1973;79(4):500-504.
Endocrine and Metabolism, Nephrology, Renal Replacement Therapy, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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