CARROLL M. LEEVY, M.D.; ROWEN ZETTERMAN, M.D.
LEEVY CM, ZETTERMAN R. Alcoholic Hepatitis and Corticosteroids. Ann Intern Med. 1973;79:739-740. doi: 10.7326/0003-4819-79-5-739
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Published: Ann Intern Med. 1973;79(5):739-740.
During the past decade, much progress has been made in understanding the pathobiology of alcoholic hepatitis. Prospective natural history studies indicate that 80% of patients with this lesion who continue to drink develop cirrhosis within 5 years (1); this is consistent with the finding that ethanol causes increased in-vitro incorporation of tritiated proline into collagen of biopsy specimens of alcoholic hepatitis (2). Alcoholic hepatitis occurs in only 10% to 30% of patients with a history of chronic alcoholism in which intake of alcoholic beverages is sufficient to interfere with work, social responsibilities, and proper food intake. This variation in susceptibility
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Gastroenterology/Hepatology, Tobacco, Alcohol, and Other Substance Abuse, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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