DOV GORSHEIN, M.D.; EMMANUEL C. BESA, M.D.; FRANK H. GARDNER, M.D.
GORSHEIN D, BESA EC, GARDNER FH. Acute Myelomonocytic Leukemia After Cessation of Androgen Therapy. Ann Intern Med. 1973;79:749-750. doi: 10.7326/0003-4819-79-5-749
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Published: Ann Intern Med. 1973;79(5):749-750.
To the editor: The current concept of remission in acute leukemia is associated with the degree of "cell kill"—longer remissions with greater cell kill. A cure means total cell kill. Weintraub (1) recently proposed that agents effective in therapy for acute leukemia induce differentiation of primitive stem cells.
Treatment with androgens for refractory anemia in a man who had preleukemia resulted in a stable course with a normal hemogram. Cessation of therapy was associated with the development of acute leukemia. It is speculated that androgens trigger cells into a cycle that responds to differentiating factors (erythropoietin), thus keeping the patient
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