L. A. DISTILLER, F.C.P.(S.A.); B. I. JOFFE, M.R.C.P.; H. C. SEFTEL, DIP. MED.
DISTILLER LA, JOFFE BI, SEFTEL HC. Adrenergic-Blocking Drugs in Hyperthyroidism. Ann Intern Med. 1973;79:899-900. doi: 10.7326/0003-4819-79-6-899
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Published: Ann Intern Med. 1973;79(6):899-900.
To the editor: Various sympatholytic drugs have been used in the symptomatic management of hyperthyroidism (1, 2): overall sympathetic blocking agents, non-selective beta-adrenergic blockers, and cardioselective beta-adrenergic antagonists. Because of the differing pharmacological effects of these drugs they are unlikely to be equally beneficial (3), but their relative efficacies have not been assessed objectively. We have tried to resolve the issue.
Eleven women, aged from 20 to 48 years, with clearcut clinical and biochemical evidence of primary hyperthyroidism, were studied. All had sinus tachycardia but no evidence of cardiac failure. They were hospitalized during the study. Biochemical evidence of hyperthyroidism
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Endocrine and Metabolism, Thyroid Disorders.
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