BOY FRAME, M.D., F.A.C.P.; CHARLES E. JACKSON, M.D., F.A.C.P.; WILLIAM A. REYNOLDS, M.D.; JAMES E. UMPHREY, M.D.
Grant support: AM 02901 and AM 14876, U.S. Public Health Service.
▸Requests for reprints should be addressed to Boy Frame, M.D., Henry Ford Hospital, Detroit, MI 48202.
FRAME B., JACKSON C., REYNOLDS W., UMPHREY J.; Hypercalcemia and Skeletal Effects in Chronic Hypervitaminosis A. Ann Intern Med. 1974;80:44-48. doi: 10.7326/0003-4819-80-1-44
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Published: Ann Intern Med. 1974;80(1):44-48.
The clinical features of vitamin A toxicity in a 7-year-old boy, a 16-year-old boy, and a 46-year-old man included vague skeletal pains and hypercalcemia. Experimental and clinical evidence indicates that hypervitaminosis A can cause bony resorption as well as periosteal calcification. Ingestion of excessive amounts of vitamin A should be considered in the differential diagnosis of hypercalcemia. Vitamin A preparations containing more than the minimum daily requirement for an adult (5000 units) per dose should be dispensed only by prescription.
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Endocrine and Metabolism, Nephrology, Fluid and Electrolyte Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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