STEPHEN W. ZIMMERMAN, M.D.; LAWRENCE R. HYMAN, M.D.; DAVID T. UEHLING, M.D.; PETER M. BURKHOLDER, M.D.
Grant support: AM-15159. Dr. Zimmerman is a NIH trainee, grant AM-05582; Dr. Hyman is the recipient of a Special Fellowship, AM-53086, from the U.S. Public Health Service.
Published in abstract form in Clin Res 21:591, 1973.
▸Requests for reprints should be addressed to Stephen W. Zimmerman, M.D., Department of Pathology, University of Wisconsin, 470 North Charter St., Madison, WI 53706.
ZIMMERMAN SW, HYMAN LR, UEHLING DT, BURKHOLDER PM. Recurrent Membranoproliferative Glomerulonephritis with Glomerular Properdin Deposition in Allografts. Ann Intern Med. 1974;80:169-175. doi: 10.7326/0003-4819-80-2-169
Download citation file:
Published: Ann Intern Med. 1974;80(2):169-175.
Two children with renal allografts developed membranoproliferative glomerulonephritis that was histopathologically similar to their original disease. Recurrent disease was diagnosed in biopsy specimens from one child with a cadaveric graft, at 2 and at 5½ years after transplantation. The graft remains functional at 6 years, although persistent hematuria, proteinuria, and mild renal failure are evident. The second child received a D-match kidney from her brother. Two years later recurrent glomerulonephritis and chronic graft rejection necessitated a transplant nephrectomy. Immunofluorescence microscopy of renal allografts from both patients showed glomerular deposition of C3 and properdin, with minimal or no deposition of complement-fixing immunoglobulins. Glomerular deposits of properdin factor B (C3 proactivator) were also seen in one of the children. These findings suggest that membranoproliferative glomerulonephritis may recur in renal allografts, possibly through activation of the alternate complement pathway.
Learn more about subscription options.
Register Now for a free account.
Nephrology, Rheumatology, Autoimmune Kidney Disease.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only