RICHARD A. BENDER, M.D.; HEINE HANSEN, M.D.
BENDER RA, HANSEN H. Hypercalcemia in Bronchogenic Carcinoma: A Prospective Study of 200 Patients. Ann Intern Med. 1974;80:205-208. doi: 10.7326/0003-4819-80-2-205
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Published: Ann Intern Med. 1974;80(2):205-208.
The relation of hypercalcemia, histologic cell type, and osseous neoplastic involvement was studied in 200 consecutive patients with untreated bronchogenic carcinoma. The overall frequency of hypercalcemia was 12.5%. Twenty-three percent of patients with epidermoid carcinoma, 12.7% with large-cell anaplastic carcinoma, 2.5% with adenocarcinoma, and none with small-cell carcinoma presented with or developed hypercalcemia. Fourteen of 25 patients (56%) with elevated calcium did not have osseous metastases. Osseous involvement was most frequently observed in patients with small-cell carcinoma (66%) and adenocarcinoma (50%). The data indicate that hypercalcemia is predominantly associated with epidermoid and large-cell anaplastic carcinoma and uncommonly associated with adenocarcinoma and small-cell carcinoma, even though the latter two cell types are most frequently associated with osseous metastases.
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Endocrine and Metabolism, Nephrology, Fluid and Electrolyte Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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