CHARLES G. GEGICK, M.D.; T.S. DANOWSKI, M.D., F.A.C.P.; HECTOR F. DE LUCA, M.D.; MICHAEL F. HOLICK, M.D.
GEGICK CG, DANOWSKI T, DE LUCA HF, HOLICK MF. Idiosyncratic Reaction to 25-Hydroxylated Vitamin D3. Ann Intern Med. 1974;80:416-417. doi: 10.7326/0003-4819-80-3-416
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Published: Ann Intern Med. 1974;80(3):416-417.
To the editor: We have administered hydroxylated derivatives of cholecalciferol or vitamin D3 (25(OH)-cholecalciferol, 1,25 dihydroxycholecalciferol, and 1-alpha hydroxycholecalciferol) to a 47-year-old woman with postthyroidectomy hypothyroidism, controlled with desiccated thyroid, and hypoparathyroidism and pruritus resistant to large dosages of calcium lactate and vitamin D2 (Table 1).
In the dosages tested, each of the three hydroxylated derivatives was equally effective in controlling the severe pruritis, even though increases in serum calcium levels, if any, were slight, and the serum inorganic phosphorus remained high. Headache, nausea, vomiting, diarrhea, and fever occurred, however, in the last 4 weeks of the initial 5-month course
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