TU LIN, M.D.; JOSEPH R. TUCCI, M.D., F.A.C.P.
Seven tests of growth-hormone release were evaluated in 31 hospitalized nonobese persons without evidence of endocrine disease. Plasma growth-hormone levels were measured before and after administration of insulin, 0.1 unit/kg body weight intravenously; glucagon, 1 mg intramuscularly; levodopa, 500 mg by mouth; metyrapone, 750 mg by mouth; α 1-24-ACTH (cosyntropin), 0.25 mg intravenously; and 1 to 2 hours after the onset of nocturnal sleep, and after 15 minutes of vigorous stair climbing. Insulin uniformly stimulated growth-hormone release in all 19 persons tested, whereas 21 of 24 (87%) responded to levodopa and 17 of 21 (81%) to glucagon. ACTH stimulated growth-hormone release in only 7 of 12 persons, whereas metyrapone had no effect. A growth-hormone response to sleep was found in only 2 of 11, whereas exercise stimulated growth-hormone release in 4 of 10. Although the highest growth-hormone levels were associated with insulin hypoglycemia, these were not significantly different from levels after administration of levodopa or glucagon (P > 0.05). These data suggest that levodopa is a reasonably effective alternative to insulin hypoglycemia as a test of growth-hormone release. Its advantages are that it is given orally, and there are minor side effects. The efficacy of glucagon approaches that of levodopa.
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LIN T, TUCCI JR. Provocative Tests of Growth-Hormone Release: A Comparison of Results with Seven Stimuli. Ann Intern Med. 1974;80:464–469. doi: 10.7326/0003-4819-80-4-464
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Published: Ann Intern Med. 1974;80(4):464-469.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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