JOSE STRAUSS, M.D.; MICHAEL KOSS, M.D.; WILLIAM GRISWOLD, M.D.; WILLIAM CHERNACK, M.D.; VlTORIANO PARDO, M.D.; RAWLE M. MCINTOSH, M.D.
STRAUSS J, KOSS M, GRISWOLD W, CHERNACK W, PARDO V, MCINTOSH RM. Cryoprecipitable Immune Complexes, Nephropathy, and Sickle-Cell Disease. Ann Intern Med. 1974;81:114-115. doi: 10.7326/0003-4819-81-1-114
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Published: Ann Intern Med. 1974;81(1):114-115.
To the editor: We have previously reported the presence of cryoproteins in immune-complex mediated glomerulonephritis in man (1) and shown that these cold insoluble serum precipitates contain antigen and specific antibody in experimental serum sickness (2). Previously (3, 4), we described an immune complex glomerulonephropathy associated with sickle-cell disease and implicated renal tubular antigen in the pathogenesis of the renal lesion. We report here the isolation and characterization of a cold insoluble complex of renal tubular antigen and antibody from a patient with sickle-cell nephropathy and autologous immune complex nephritis.
Blood was obtained from a patient with sickle-cell disease and
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Hematology/Oncology, Red Cell Disorders.
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