WILLIAM A. PARKER, PHARM. D.
To the editor: Primidone-induced hematologic reactions are generally quite rare. As discussed by Booker (1), primidone has been implicated in producing folic acid deficiency and megaloblastic anemia after continual administration. Hemorrhagic disease of newborns and leukopenia have also been reported (1), but rarely, and Rozbicka (2) has reported one patient with thrombocytopenic purpura. In general, authors reporting on large series of patients have commented on the relative immunity of the bone marrow to adverse effects of primidone. The following case report describes a primidone-induced thrombocytopenia.
The patient was a 26-year-old white woman with major motor seizures and a history of
Learn more about subscription options.
Register Now for a free account.
PARKER WA. Primidone Thrombocytopenia. Ann Intern Med. 1974;81:559–560. doi: 10.7326/0003-4819-81-4-559
Download citation file:
Published: Ann Intern Med. 1974;81(4):559-560.
Hematology/Oncology, Platelet Disorders.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only