CHARLES S. WHITE, M.D.; WILLIAM H. ADLER, M.D.; VIRGINIA G. McGANN, Ph.D.
WHITE CS, ADLER WH, McGANN VG. Repeated Immunization: Possible Adverse Effects: Reevaluation of Human Subjects at 25 Years. Ann Intern Med. 1974;81:594-600. doi: 10.7326/0003-4819-81-5-594
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Published: Ann Intern Med. 1974;81(5):594-600.
A group of intensively immunized men, who had been subjected to detailed medical evaluations in 1956 and in 1962, was reexamined in 1971 and compared with a carefully matched control group. Clinical and laboratory studies were done to detect adverse effects induced by repeated parenteral inoculation with a variety of vaccines and toxoids. No clinical sequels attributable to long-term immunization were identified. Only one laboratory abnormality described in previous studies, elevated serum hexosamine, was observed. Few other abnormalities were detected in the immunized group; mean values were depressed for serum
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Infectious Disease, Prevention/Screening, Vaccines/Immunization.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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