RICHARD S. STEIN, M.D.; EDGAR M. MORAN, M.D.; RICHARD K. DESSER, M.D.; J. BRUCE MILLER, M.D.; HARVEY M. GOLOMB, M.D.; JOHN E. ULTMANN, M.D., F.A.C.P.
STEIN RS, MORAN EM, DESSER RK, MILLER JB, GOLOMB HM, ULTMANN JE. Combination Chemotherapy of Lymphomas Other Than Hodgkin's Disease. Ann Intern Med. 1974;81:601-608. doi: 10.7326/0003-4819-81-5-601
Download citation file:
Published: Ann Intern Med. 1974;81(5):601-608.
The efficacy and toxicity of two regimens of combination chemotherapy were compared in patients with lymphoma, other than Hodgkin's disease, in pathologic stage IV. Patients were assigned by unrestricted randomization to receive either vincristine and prednisone or cyclophosphamide, vincristine, procarbazine, and prednisone (COPP). Patients who didn't have complete remission on vincristine and prednisone were switched to COPP. In the randomized trial COPP was superior to vincristine and prednisone, in the rates of induction of complete remission, which were 58% and 14%, respectively (P < 0.005). Of 32 patients receiving COPP, the rate of induction of complete remission was 59% and the median length of complete remission was greater than 18 months. COPP produced a complete remission in 18 of 26 patients with lymphoma other than histiocytic lymphoma. These results compare favorably with those of previously reported regimens. The value of COPP in patients with lymphoma seems to have been shown.
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only