STEVEN B. LEICHTER, M.D.; WILLIAM H. DAUGHADAY, M.D.
A 48-year-old woman with mild hirsutism had extremely elevated urinary excretion of 17-ketosteroids (as high as 1555 mg per day). At operation, a large, benign adenoma was found. The case was unusual in that she had severe hypocholesterolemia that was first documented 2 years before surgery. Postoperatively, plasma cholesterol levels promptly returned to normal. It is proposed that the markedly elevated production of steroid substances by this tumor led to a massive diversion of plasma cholesterol, exceeding any compensatory increase in hepatic cholesterol synthesis. This consequence of steroid overproduction has hitherto been unrecognized.
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LEICHTER SB, DAUGHADAY WH. Massive Steroid Excretion and Hypocholesterolemia with an Adrenal Adenoma: Report of a Case. Ann Intern Med. 1974;81:638-640. doi: 10.7326/0003-4819-81-5-638
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Published: Ann Intern Med. 1974;81(5):638-640.
Adrenal Disorders, Cardiology, Coronary Risk Factors, Dyslipidemia, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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