LAWRENCE WALLACH, M.D.; ILDIKO NYARAI; KEITH G. DAWSON, M.D., Ph.D., F.A.C.P., F.R.C.P. (C)
WALLACH L, NYARAI I, DAWSON KG. Stimulated Renin: A Screening Test for Hypertension. Ann Intern Med. 1975;82:27-34. doi: 10.7326/0003-4819-82-1-27
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Published: Ann Intern Med. 1975;82(1):27-34.
The usefulness of the furosemide screening test in ambulant hypertensive patients was prospectively studied. Outpatients were given 60 mg of furosemide by mouth, and 5 hours later plasma renin activity was measured. Subsequent investigation in hospital showed that the patients fell into four groups: extreme hyporeninemia (primary aldosteronoma), suppressed renin (confirmed suppressed-renin hypertension), normal renin (essential hypertension), and elevated renin (renovascular hypertension). The plasma renin activity measured by the test correlated well with standardized in-hospital measurement. This test identifies patients who may have primary aldosteronism, suppressed-renin hypertension, or renovascular disease as the cause of hypertension, thus indicating those requiring further in-hospital investigation. More significantly, it identifies those not requiring further study, thus decreasing hospitalization. Finally, it helps in the selection of specific antihypertensive therapy based on plasma renin activity.
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Cardiology, Coronary Risk Factors, Hypertension, Nephrology, Prevention/Screening.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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