JOHN MERRILL, M.D.; F. ANTHONY GRECO, M.D.; HARVEY ZIMBLER, M.D.; HARMAR D. BRERETON, M.D.; JOHN D. LAMBERG, M.D.; THOMAS C. POMEROY, M.D.
To the editor: Severe cardiomyopathy with irreversible congestive heart failure from adriamycin is very rare if the dose is limited to below 500 to 550 mg/m2 body surface area (1, 2). We have seen two patients who developed severe cardiac failure after receiving less than 500 mg/m2 body surface area of adriamycin in conjunction with therapeutic radiation to the thoracic spine and lungs. This seems to be a variable in the development of adriamycin cardiotoxicity.
An 11-year-old girl with Ewing's sarcoma of the right ilium metastatic to the skull and thoracic spine has been treated since 1972 with
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MERRILL J, GRECO FA, ZIMBLER H, BRERETON HD, LAMBERG JD, POMEROY TC. Adriamycin and Radiation: Synergistic Cardiotoxicity. Ann Intern Med. 1975;82:122–123. doi: 10.7326/0003-4819-82-1-122_2
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Published: Ann Intern Med. 1975;82(1):122-123.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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