JOEL D. MEYERS, M.D.; HARRISON C. SPENCER, M.D., M.P.H.; JOHN C. WATTS, M.D.; MICHAEL B. GREGG, M.D.; JOHN A. STEWART, M.D.; ROSALIND H. TROUPIN, M.D.; E. DONNALL THOMAS, M.D.
Thirty-three of 85 patients undergoing marrow transplantation between 1969 and 1973 developed interstitial pneumonia; 23 died. The clinical syndrome consisted of tachypnea, cough, fever, rales, and hypoxemia; the radiologic findings were variable. The development of interstitial pneumonia was significantly associated with graft-versus-host disease and allogenic grafting; patients with isogenic grafts were relatively spared. The increased attack rate between 1969-71 (20%) and 1972-73 (49%) was not fully explained by improved long-term survival, by an increased proportion of allogenic transplants, or by an increased incidence of graft-versus-host disease. Intranuclear inclusions typical of cytomegalovirus were identified in 9 of 17 autopsy-confirmed cases, and patients whose marrow donors had positive cytomegalovirus antibody titers developed interstitial pneumonia more often than patients whose donors had negative titers. Interstitial pneumonia is an important cause of morbidity and mortality after human marrow transplantation. No effective treatment is presently available.
Learn more about subscription options.
Register Now for a free account.
MEYERS JD, SPENCER HC, WATTS JC, GREGG MB, STEWART JA, TROUPIN RH, et al. Cytomegalovirus Pneumonia After Human Marrow Transplantation. Ann Intern Med. 1975;82:181-188. doi: 10.7326/0003-4819-82-2-181
Download citation file:
Published: Ann Intern Med. 1975;82(2):181-188.
Hematology/Oncology, Infectious Disease.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only