J. ROGER EDSON, M.D.; DENNIS R. FECHER, M.D.; RICHARD P. DOE, M.D., Ph.D.
EDSON JR, FECHER DR, DOE RP. Low Platelet Adhesiveness and Other Hemostatic Abnormalities in Hypothyroidism. Ann Intern Med. 1975;82:342-346. doi: 10.7326/0003-4819-82-3-342
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Published: Ann Intern Med. 1975;82(3):342-346.
Fifteen patients with definite hypothyroidism and two with probable hypothyroidism had extensive hemostatic profiles done. In 12 of the 16 patients tested, the platelet adhesiveness (platelet retention in a glass bead column) was abnormal, and in 1 more it was borderline. In the six patients who were studied repeatedly, hemostatic abnormalities either markedly improved or disappeared after treatment with L-thyroxine. It is concluded that, in addition to the previously reported coagulation factor deficiencies (which we also observed in some of our patients), low platelet adhesiveness occurs frequently in patients with hypothyroidism.
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Endocrine and Metabolism, Thyroid Disorders.
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