GORDON L. BILBREY, M.D.; GERALD R. FALOONA, Ph.D.; MARTIN G. WHITE, M.D.; CAROLYN ATKINS, R.N.; ALAN R. HULL, M.D.; JAMES P. KNOCHEL, M.D.
Chronic renal failure in man is associated with hyperglucagonemia that is not corrected by hemodialysis. Plasma glucagon concentrations were measured in nine patients before and after renal transplantation. Mean plasma glucagon concentration in eight patients with chronic renal failure before transplantation was 295 ± 171 pg/ml (± SD). After successful transplantation, mean plasma glucagon concentration fell to 134 ± 81 pg/ml (± SD) (P < 0.001). Plasma glucagon concentration remained elevated in an additional patient who received a cadaveric graft that never functioned. Immunologic rejection of transplanted kidneys was associated with a dramatic increase of plasma glucagon concentration.
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BILBREY GL, FALOONA GR, WHITE MG, ATKINS C, HULL AR, KNOCHEL JP. Hyperglucagonemia in Uremia: Reversal by Renal Transplantation. Ann Intern Med. 1975;82:525-528. doi: 10.7326/0003-4819-82-4-525
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Published: Ann Intern Med. 1975;82(4):525-528.
Nephrology, Renal Replacement Therapy.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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