A. KADRI, M.D.; M. MOINUDDIN, M.D., F.R.C.P.(C); N. K. M. de LEEUW, M.D., F.A.C.P., F.R.C.P.(C)
A 43-year-old woman who developed thrombotic thrombocytopenic purpura was treated successfully with high doses of prednisone and a splenectomy. Imprints from the cut surface of the spleen showed marked phagocytosis of all the cellular elements of the blood. This observation suggests that hypersplenism, in addition to vascular occlusion, may play a major role in the physiopathology of some cases of thrombotic thrombocytopenic purpura.
Learn more about subscription options.
Register Now for a free account.
KADRI A, MOINUDDIN M, de LEEUW NKM. Phagocytosis of Blood Cells by Splenic Macrophages in Thrombotic Thrombocytopenic Purpura. Ann Intern Med. 1975;82:799–802. doi: 10.7326/0003-4819-82-6-799
Download citation file:
Published: Ann Intern Med. 1975;82(6):799-802.
Coagulopathies, Hematology/Oncology, Platelet Disorders.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only