G. THEODOROPOULOS, M.D.; A. ARCHIMANDRITIS, M.D.; B. ANGELOPOULOS, M.D.
In 1970 Sherlock and co-workers (1) were the first to describe five cases of malignant hepatoma associated with a positive Au(1) serologic test. Some months later, there was a report of a high prevalence of Au(1) in the serum of Ugandan patients with hepatocellular carcinoma. These findings "provided suggestive evidence that virus hepatitis B at least is a precancerous condition" (2). However, the results of other investigations carried out in different areas of the world to establish this association are controversial. A high prevalence of Au(1) has been observed in patients suffering from hepatoma in Senegal, Uganda, India, Spain, Chile,
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THEODOROPOULOS G, ARCHIMANDRITIS A, ANGELOPOULOS B. Australia Antigen and Malignant Hepatoma. Ann Intern Med. 1975;82:809–810. doi: 10.7326/0003-4819-82-6-809
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Published: Ann Intern Med. 1975;82(6):809-810.
Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Liver Cancer, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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