BRUCE M. GREENE, M.D.; FRANK E. THOMAS, M.D.; ROBERT H. ALFORD, M.D., F.A.C.P.
We recently treated a patient with a brain abscess with trimethoprim-sulfamethoxazole (TM-SMX), an antimicrobial combination that is relatively new in this country. We were able to document penetration of the drug into the abscess by measuring levels in pus obtained at craniotomy.
This 35-year-old man was found to have bilateral mastoiditis in July 1973 with an air-fluid level in the mastoid bone on the right. He refused surgical intervention until October 1973, when he underwent a right tympanoplasty and mastoidectomy. Postoperatively, drainage from the right ear resumed, which grew Proteus mirabilis. Gentamicin and cephalothin therapy was begun in another hospital.
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GREENE BM, THOMAS FE, ALFORD RH. Trimethoprim-Sulfamethoxazole and Brain Abscess. Ann Intern Med. 1975;82:812-813. doi: 10.7326/0003-4819-82-6-812
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Published: Ann Intern Med. 1975;82(6):812-813.
CNS Infections, Infectious Disease, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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