GORDON C. WEIR, M.D.; PAUL B. LESSER, M.D.; LAMBERTUS J. DROP, Ph.D., M.D.; JOSEF E. FISCHER, M.D.; ANDREW L. WARSHAW, M.D.
WEIR GC, LESSER PB, DROP LJ, FISCHER JE, WARSHAW AL. The Hypocalcemia of Acute Pancreatitis. Ann Intern Med. 1975;83:185-189. doi: 10.7326/0003-4819-83-2-185
Download citation file:
Published: Ann Intern Med. 1975;83(2):185-189.
Variables of calcium metabolism were measured in 11 patients with clearly documented acute pancreatitis. Total and ionized calcium levels were either low or in the low-normal range as were phosphorus and total magnesium levels. Parathyroid hormone levels were high, and there was a significant inverse correlation with ionized calcium. Gastrin levels were normal, calcitonin values were uniformly below the detection limit of the assay, and pancreatic glucagon levels were elevated. The hypocalcemia of acute pancreatitis was probably not caused by abnormalities of glucagon, calcitonin, or gastrin secretion. Furthermore, parathyroid hormone secretion was apparently not impaired. Hypomagnesemia possibly played a minor role. This study suggests that the hypocalcemia of acute pancreatitis is secondary to extraskeletal calcium sequestration or an as yet unidentified defect of bone metabolism, or both.
Learn more about subscription options.
Register Now for a free account.
Endocrine and Metabolism, Gastroenterology/Hepatology, Nephrology, Fluid and Electrolyte Disorders, Pancreatic Disease.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only