ALEXANDER A. ANDRIANAKOS, M.D.; JOSEPH DUFFY, M.D.; MINORU SUZUKI, M.D.; JOHN T. SHARP, M.D., F.A.C.P.
Three cases of transverse myelopathy associated with systemic lupus erythematosus were reported, and 23 similar cases previously reported were reviewed. A diagnosis of systemic lupus erythematosus was made in only 60% before the onset of transverse myelopathy. The time of onset of myelopathy was randomly distributed during the disease. The most common presenting neurologic symptom was numbness, or weakness of the legs, or both. A unique association between the acute stage of transverse myelopathy and marked reduction of cerebrospinal fluid glucose concentration was observed. Thirteen patients died, 9 had permanent neurologic deficits, and only 4 recovered nearly normal function. Eight patients had Ischemic necrosis of the spinal cord at postmortem examination, and vascular lesions were found in the spinal cord of 3 additional patients. The value of steroid treatment was uncertain. Patients who were started on steroid therapy within 24 hours of the onset of myelopathy may have benefited.
Learn more about subscription options.
Register Now for a free account.
ANDRIANAKOS AA, DUFFY J, SUZUKI M, SHARP JT. Transverse Myelopathy in Systemic Lupus Erythematosus: Report of Three Cases and Review of the Literature. Ann Intern Med. 1975;83:616-624. doi: 10.7326/0003-4819-83-5-616
Download citation file:
Published: Ann Intern Med. 1975;83(5):616-624.
Infectious Disease, Lupus Erythematosus, Neurology, Rheumatology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only