DAVID A. CHERRILL, M.D.; ROBERT M. STOTE, M.D.; JAMES R. BIRGE, M.D.; IRWIN SINGER, M.D., F.A.C.P.
We have studied the effects of demeclocycline on the water metabolism of a patient with the syndrome of inappropriate antidiuretic hormone (ADH) secretion who presented with a serum sodium concentration of 110 meq/litre. Free water clearance was studied before, during, and after treatment with demeclocycline. This study shows that demeclocycline (900 mg/day) can at least partially inhibit the action of ADH in the setting of tumor-induced ADH secretion, with the production of a reversible, partial nephrogenic diabetes insipidus, and with few or no side effects. Demeclocycline may be useful in the treatment of chronic inappropriate ADH secretion.
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CHERRILL DA, STOTE RM, BIRGE JR, SINGER I. Demeclocycline Treatment in the Syndrome of Inappropriate Antidiuretic Hormone Secretion. Ann Intern Med. 1975;83:654–656. doi: 10.7326/0003-4819-83-5-654
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Published: Ann Intern Med. 1975;83(5):654-656.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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