MARK DONOWITZ, M.D.; ROSA HENDLER, M.D.; HOWARD M. SPIRO, M.D., F.A.C.P.; HENRY J. BINDER, M.D.; PHILIP FELIG, M.D., F.A.C.P.
Plasma pancreatic glucagon concentrations were determined in the basal state and after the infusion of alanine in 10 patients with acute pancreatitis (5 in an initial episode of pancreatitis), in 10 patients with chronic pancreatic insufficiency, and in 21 healthy controls. In acute pancreatitis, basal glucagon levels were nine times normal but were higher during the initial attack than with a history of previous attacks. The glucagon response to alanine was also increased threefold to fourfold in initial attacks. In contrast, after recovery from the initial attack of acute pancreatitis, during acute episodes of pancreatitis in patients with a history of previous attacks, and in patients with pancreatic insufficiency, alanine failed to elicit a consistent rise in plasma glucagon. The data suggest that hyperglucagonemia may contribute to the hyperglycemia of acute pancreatitis, particularly during the initial episode. Loss of alpha cell responsiveness to alanine provides a sensitive index of previous pancreatitis.
Learn more about subscription options.
Register Now for a free account.
DONOWITZ M, HENDLER R, SPIRO HM, BINDER HJ, FELIG P. Glucagon Secretion in Acute and Chronic Pancreatitis. Ann Intern Med. 1975;83:778-781. doi: 10.7326/0003-4819-83-6-778
Download citation file:
Published: Ann Intern Med. 1975;83(6):778-781.
Gastroenterology/Hepatology, Pancreatic Disease.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only