L. KENT SMITH, M.D.; RUSSELL V. LUEPKER, M.D.; SARAH S. ROTHCHILD, M.S.; ALBERT GILLIS, M.P.H.; LEON KOCHMAN, M.D.; J. RICHARD WARBASSE, M.D., F.A.C.P.
A lipid intervention clinic screened 4000 employees (89% participation) and identified 150 type IV subjects (top 5 percentile triglyceride values, 100% initial participation, 6% drop out). The 150 healthy type IV subjects, ages 20 to 49, were randomly divided into treatment subgroups: A, treatment by clinic nutritionist and physician with the National Heart and Lung Institute's type IV diet for 6 weeks, then diet plus Clofibrate for 18 weeks; B, same treatment by private physician; C, no intervention for 24 weeks, subjects advised of abnormality. The group A mean fasting serum triglyceride of 407 mg/dl declined 50% at 6 weeks, 61% at 12 weeks, and was unchanged at 24 weeks (P < 0.0005 at 6, 12, 24 weeks). Group B triglyceride decreased 42%, 50%, 41% (P < 0.0005 at 6, 12, 24 weeks). Group C triglyceride declined 20%, 1st to 24th week. Body weight decreased 8% (A) and 4% (B) at 6 weeks (P < 0.0005) and was unchanged at 24 weeks. The maximum cholesterol decrease (A) was 11% (P < 0.0005). Type IV hyperlipoproteinemia can readily be identified in a working population; treatment by clinic or private physician will markedly lower fasting serum triglyceride values in apparently healthy type IV subjects for at least 24 weeks.
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SMITH LK, LUEPKER RV, ROTHCHILD SS, GILLIS A, KOCHMAN L, WARBASSE JR. Management of Type IV Hyperlipoproteinemia: Evaluation of Practical Clinical Approaches. Ann Intern Med. 1976;84:22–28. doi: 10.7326/0003-4819-84-1-22
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Published: Ann Intern Med. 1976;84(1):22-28.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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