JOHN MILLS, M.D.; DENIS DREW, M.D.
MILLS J, DREW D. Serratia marcescens Endocarditis: A Regional Illness Associated with Intravenous Drug Abuse. Ann Intern Med. 1976;84:29-35. doi: 10.7326/0003-4819-84-1-29
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Published: Ann Intern Med. 1976;84(1):29-35.
From 1969 to 1974, 19 cases of Serratia marcescens endocarditis were observed in the San Francisco Bay Area. Seventeen patients were intravenous drug users, and Serratia caused 14% of all addict-associated endocarditis in San Francisco. Serratia strains were nonpigmented and had typical antibiotic sensitivities, except that 9 of the isolates exhibited colonial variation, with each variant having different antibiotic sensitivities. Aortic or mitral valves were involved in 13 patients, and heart failure developed in 9 of these. Twelve patients had embolic episodes to brain, iliofemoral arteries, or lung. Five of 6 patients with tricuspid valvulitis were cured by antibiotics either with (1) or without excision of the valve. All 12 patients with aortic or mitral valvulitis treated medically died; 11 had unremitting sepsis. Aortic valve replacement and antibiotics were effective in 1. Gentamicin combined with either carbenicillin or chloramphenicol was the most effective treatment regimen.
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Cardiology, Infectious Disease, Tobacco, Alcohol, and Other Substance Abuse, Endocarditis.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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