FREDERICK L. GLAUSER, M.D.; WILLIAM RICHARD SMITH, M.D.; ALEX CALDWELL, M.D.; MELVIN HOSHIKO, M.D.; GEOFFREY S. DOLAN, M.D.; HAROLD BAER, M.D.; NEAL OLSHER, M.D.
Two patients experienced severe nonhemodynamic pulmonary edema following the intravenous injection of 25 and 40 mg/kg of body weight of ethchlorvynol (Placidyl⌖). The pulmonary edema cleared rapidly. Injection of Placidyl (12 to 80 mg/kg of body weight) intravenously into dogs caused acute, severe, nonhemodynamic pulmonary edema (as evidenced by markedly elevated lung weights and microscopic evidence of intra-alveolar edema), hypotension with a relative bradycardia, and a decreased cardiac output. Injection of polyethylene glycol, the vehicle in which ethchlorvynol is diluted, did not reproduce the syndrome.
Learn more about subscription options.
Register Now for a free account.
GLAUSER FL, SMITH WR, CALDWELL A, HOSHIKO M, DOLAN GS, BAER H, et al. Ethchlorvynol (Placidyl⌖)-Induced Pulmonary Edema. Ann Intern Med. 1976;84:46–48. doi: 10.7326/0003-4819-84-1-46
Download citation file:
Published: Ann Intern Med. 1976;84(1):46-48.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only