IRA M. GOLDSTEIN, M.D., F.A.C.P.; JAN K. HORN, B.S.; HOWARD B. KAPLAN, M.S.; ROY SOBERMAN, M.D.; GERALD WEISSMANN, M.D.
GOLDSTEIN IM, HORN JK, KAPLAN HB, SOBERMAN R, WEISSMANN G. Hypercalcemia: A Possible Cause for Elevated Serum Lysozyme Levels. Ann Intern Med. 1976;84:445-446. doi: 10.7326/0003-4819-84-4-445
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Published: Ann Intern Med. 1976;84(4):445-446.
Lysozyme is a normal constituent of the cytoplasmic granules (lysosomes) of human peripheral blood polymorphonuclear leukocytes (1). We have recently found that these cells can be stimulated to release, or secrete, a portion of their lysozyme activity when exposed to ionized calcium (at concentrations as low as 0.01 mM) (2, 3). Since it was possible that conditions for such lysozyme release could occur in vivo, we elected to study serum lysozyme activity in patients with various disorders associated with hypercalcemia.
Serum samples were obtained from 16 patients with hypercalcemia (6 with primary hyperparathyroidism and 10 with nonhematologic malignancies). Total serum
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Endocrine and Metabolism, Nephrology, Fluid and Electrolyte Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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