STANLEY A. BLUMENTHAL, M.D., F.A.C.P.; DAVID H. P. STREETEN, M.B., D.PHIL., F.R.C.P.
To the editor: We wish to correct a statement that appeared in our recent "Letter" (Ann Intern Med 84:55-56, 1976). In our discussion of a patient with phenformin-related lactic acidosis, we indicated that the increase in phosphofructokinase activity, and hence the increase in glycolytic production of lactic acid, was caused by a fall in cytosolic ATP concentration. This is probably not true. Current biochemical evidence suggests that intracellular ATP levels do not regulate glycolysis because they change very little, even under anoxic conditions, and that increases or decreases in phosphofructokinase activity are closely related to concordant changes in cytosolic AMP
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BLUMENTHAL SA, STREETEN DHP. Phenformin and Lactic Acidosis. Ann Intern Med. 1976;84:615–616. doi: 10.7326/0003-4819-84-5-615
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Published: Ann Intern Med. 1976;84(5):615-616.
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