PAUL D. BERK, M.D., F.A.C.P.; JAMES F. MARTIN, M.D.; ROBERT S. YOUNG, M.D., F.A.C.P.; JOHN CREECH, M.D.; IRVING J. SELIKOFF, M.D.; HENRY FALK, M.D.; PHILIP WATANABE, Ph.D.; HANS POPPER, M.D., F.A.C.P.; LOUIS THOMAS, M.D.
Although polyvinyl chloride has been produced from vinyl chloride monomer for more than 40 years, recognition of toxicity among vinyl chloride polymerization workers is more recent. In the mid 1960s, workers involved in cleaning polymerization tanks were found to have acro-osteolysis. In 1974, the same population of workers was found to be at risk for an unusu al type of hepatic fibrosis and angiosarcoma of the liver. We describe two cases of vinyl chloride-associated liver injury, one of hepatic fibrosis and one of angiosarcoma. Histologic features of these lesions are similar to the hepatic fibrosis and angiosarcomas resulting from chronic exposure to inorganic arsenicals. Preliminary studies suggest that the toxicity of vinyl chloride may result from formation, during high-dose exposure, of active metabolites by mixed function oxidases of the liver. Epidemiologic studies indicate an increased incidence not only of liver disease, but also of cancers of the brain, lung, and possibly other organs.
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BERK PD, MARTIN JF, YOUNG RS, CREECH J, SELIKOFF IJ, FALK H, et al. Vinyl Chloride-Associated Liver Disease. Ann Intern Med. 1976;84:717–731. doi: 10.7326/0003-4819-84-6-717
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Published: Ann Intern Med. 1976;84(6):717-731.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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