RUFINO C. PABICO, M.D.; R. GORDON DOUGLAS, M.D., F.A.C.P.; ROBERT F. BETTS, M.D.; BARBARA A. McKENNA, M.S.; RICHARD B. FREEMAN, M.D., F.A.C.P.
Thirty renal transplant recipients received 0.5 ml of Influenza Virus Vaccine, Bivalent, USP, intramuscularly. Serum hemagglutination-inhibiting and nasal secretory neutralizing antibodies were measured before and 3 to 4 weeks after vaccination. Creatinine clearance and urinary protein excretion were measured before and weekly for 4 to 8 weeks after vaccination. Ten of 13 patients (77%) with creatinine clearance of ≥ 70 ml/min·1.73m2 (group I) had ≥ a fourfold increase in hemagglutination-inhibiting antibody titers to influenza A or B virus after vaccination, while only six of 17 patients (35%) with creatinine clearance of < 70 ml/min·1.73m2 (group II) had a similar increase (chi-square = 5.129; P < 0.05). Six of 13 patients (46%) in group I had ≥ a fourfold increase in neutralizing antibody titers to influenza A or B virus after vaccination, whereas none in group II had a similar increase (chi-square = 7.135; P < 0.01). There were no adverse effects on the allografts. Only minor side effects were noted in a few patients. Because of its safety and antigenicity, influenza vaccination should be offered to renal transplant recipients particularly during threats of epidemic outbreaks.
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PABICO RC, DOUGLAS RG, BETTS RF, McKENNA BA, FREEMAN RB. Antibody Response to Influenza Vaccination in Renal Transplant Patients: Correlation with Allograft Function. Ann Intern Med. 1976;85:431–436. doi: 10.7326/0003-4819-85-4-431
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Published: Ann Intern Med. 1976;85(4):431-436.
Infectious Disease, Influenza, Nephrology, Prevention/Screening, Renal Replacement Therapy.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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