JOSEPH G. SINKOVICS, M.D., F.A.C.P.; FERENC GYÖRKEY, M.D.; PHYLLIS GYÖRKEY, B.S.; CHIU-HWA WANG, M.D.
SINKOVICS JG, GYÖRKEY F, GYÖRKEY P, WANG C. Hairy Cells in Long-Term Cultures. Ann Intern Med. 1976;85:532-533. doi: 10.7326/0003-4819-85-4-532
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Published: Ann Intern Med. 1976;85(4):532-533.
To the editor: The derivation of hairy cells is unsettled because arguments can be put forward for both monocytic and lymphocytic origins. In a recent report (1), lymphocytic derivation of hairy cells was suggested on the basis of short term in-vitro cultures of these cells. However, established long-term cultures of hairy cells are available (2), and these cells behave like lymphoid cells of B lineage. These cells stain for surface immunoglobulin IgG, are positive for tartrate-resistant acid phosphatase, and contain herpes virus particles resembling those of the Epstein-Barr virus (Figure 1A). In addition, these cells have unusually long and numerous
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