MARK D. FISCHER, M.D.; HIBBARD E. WILLIAMS, M.D.
FISCHER MD, WILLIAMS HE. Rhabdomyolysis and Renal Failure. Ann Intern Med. 1976;85:537. doi: 10.7326/0003-4819-85-4-537_1
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Published: Ann Intern Med. 1976;85(4):537.
To the editor: In light of the patient population at San Francisco General Hospital, we read with interest the recent article on renal failure and rhabdomyolysis by Koffl;er, Friedler, and Massry (Ann Intern Med 85:23-28, 1976). The magnitude of hyperuricemia is an aspect of this syndrome we have seen in several patients. The mechanism postulated by the authors for the elevated serum level, that is, "increased liberation of adenine nucleotides by muscle," is plausible in view of a concomitant 24-h hyperuricosuria in patients with heat stress, exercise, and muscle injury as described by Knochel, Dotin, and Hamburger (1). Elevated urinary
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