RONALD N. RUBIN, M.D.; EDWARD R. BURKA, M.D.
Cephalothin therapy is associated with a positive direct antiglobulin test in 3% to 65% of patients receiving this drug (1, 2). Most often the responsible mechanism is nonimmune adsorption of serum proteins to cephalothin-exposed erythrocytes (3). Cephalothin-related hemolysis has been reported and is associated with specific anticephalothin antibodies (4, 5). We describe here a case of cephalothin-related Coombs' positive hemolytic anemia in which IgG antibody has been identified in the patient's serum and on erythrocytes.
A 64-year-old white man was admitted to Thomas Jefferson University Hospital on 3 August 1975, for evaluation of chills
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RUBIN RN, BURKA ER. Anti-Cephalothin Antibody and Coombs'-Positive Hemolytic Anemia. Ann Intern Med. 1977;86:64-65. doi: 10.7326/0003-4819-86-1-64
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Published: Ann Intern Med. 1977;86(1):64-65.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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