JAMES A. O'CONNOR, M.D., F.A.C.P., F.A.I.C.
To the editor: In a recent editorial by Stauffer and Hill (1), "Systemic Contraceptives and Liver Tumors," we find repeated again a common misstatement that "both the synthetic estrogens and progesterones used in many of the oral contraceptive preparations are 17α-alkyl-substituted steroids" [italics added]. The facts are that no synthetic estrogen used in any contraceptive ever sold in United States and no synthetic progestogen used currently or during the past many years is a 17α-alkyl-substituted steroid.
The editorial then goes on to enumerate many hepatotoxic effects reported as due to synthetic estrogens and progestogens, two classes of hormones that are
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O'CONNOR JA. Hepatotoxicity and the Oral Contraceptives. Ann Intern Med. 1977;86:118–119. doi: 10.7326/0003-4819-86-1-118_2
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Published: Ann Intern Med. 1977;86(1):118-119.
Emergency Medicine, Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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