CURT A. RIES, M.D.
RIES CA. Platelet Kinetics in Autoimmune Thrombocytopenia: Relation Between Splenic Platelet Sequestration and Response to Splenectomy. Ann Intern Med. 1977;86:194-195. doi: 10.7326/0003-4819-86-2-194
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Published: Ann Intern Med. 1977;86(2):194-195.
The usefulness of 51Cr platelet survival and sequestration studies in predicting response to splenectomy in idiopathic thrombocytopenic purpura and other autoimmune thrombocytopenias remains controversial (1). In one large series of patients with idiopathic thrombocytopenic purpura who had platelet kinetic studies before splenectomy, 81% of patients with splenic sequestration had complete remissions, whereas only 38% of those with splenic and hepatic or "diffuse" sequestration, and 9% of those with hepatic sequestration, had complete remissions (2). Other investigators have reported less consistent results in smaller numbers of patients (3, 4). We found a 93% complete remission rate among 15 patients with idiopathic
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Hematology/Oncology, Platelet Disorders, Coagulopathies.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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