JOHN L. ZIEGLER, M.D.; IAN T. MAGRATH, M.B., M.R.C.P.; PAUL GERBER, Ph.D.; PAUL H. LEVINE, M.D.
The association of the Epstein-Barr virus and two human malignancies, Burkitt's lymphoma and nasopharyngeal carcinoma, is reviewed. Seroepidemiologic, virologic, and immunologic evidence is summarized, and several hypotheses regarding a possible etiologic role for the Epstein-Barr virus in these tumors are presented. With our current state of knowledge we cannot conclude that the Epstein-Barr virus is oncogenic in man, nor can we yet ascertain the biological and clinical significance of its association with Burkitt's lymphoma and nasopharyngeal carcinoma.
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ZIEGLER JL, MAGRATH IT, GERBER P, LEVINE PH. Epstein-Barr Virus and Human Malignancy. Ann Intern Med. 1977;86:323–336. doi: 10.7326/0003-4819-86-3-323
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Published: Ann Intern Med. 1977;86(3):323-336.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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